English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Ricinus communis  L. is a medicinal plant that displays valuable pharmacological properties, including antioxidant, antimicrobial, analgesic, antibacterial, antiviral and anti-inflammatory properties. This study targeted to isolate and identify some constituents of  R. communis  leaves using ultra-performance liquid chromatography coupled with mass spectroscopy (UPLC-MS/MS) and different chromatographic techniques.  In vitro  anti-MERS and anti-SARS-CoV-2 activity for different fractions and for two pure isolated compounds, lupeol (RS) and ricinine (RS1) were evaluated using a plaque reduction assay with three different mechanisms and IC 50  based on their cytotoxic concentration (CC 50 ) from an MTT assay using Vero E6 cell line. Isolated phytoconstituents and remdesivir are assessed for  in-silico  anti-COVID-19 activity using molecular docking tools. The methylene chloride extract showed pronounced virucidal activity against SARS-CoV-2 (IC 50  = 1.76 μg/ml). It was also shown that ricinine had superior potential activity against SARS-CoV-2, (IC 50  = 2.5 μg/ml). Lupeol displayed the most potency against MERS, (IC 50  = 5.28 μg/ml). Ricinine appeared to be the most biologically active compound. The study showed that  R. communis  and its isolated compounds have potential natural virucidal activity against SARS-COV-2; however, additional exploration is necessary and study for their  in vivo  activity.

Anti-SARS-CoV-2 in vitro potential of castor oil plant ( Ricinus communis ) leaf extract: in-silico virtual evidence