English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Phytochemical profiles of essential oil ( EO ), fatty acids, and  n -hexane (CAH), diethyl ether (CAD), ethyl acetate (CAE) and methanol extracts (CAM) of  Cota altissima  L. J. Gay (syn.  Anthemis altissima  L.) were investigated as well as their antioxidant, anti-inflammatory, antidiabetic and antimicrobial activites. The essential oil was characterized by the content of acetophenone (35.8%) and  β -caryophyllene (10.3%) by GC-MS/FID. Linoleic and oleic acid were found as main fatty acids. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, isorhamnetin glucoside, quercetin and quercetin glucoside by LC-MS/MS. Antioxidant activities of the extracts were determined by scavenging of DPPH and ABTS free radicals. Also, the inhibitory effects on lipoxygenase and  α -glucosidase enzymes were determined. Antimicrobial activity was evaluated against Gram positive, Gram negative bacteria and yeast pathogens.  CAM  showed the highest antioxidant activity against DPPH and ABTS radicals with IC 50  values of 126.60 and 144.40 μg/mL, respectively. In the anti-inflammatory activity,  CAE  demonstrated the highest antilipoxygenase activity with an IC 50  value of 105.40 μg/mL, whereas,  CAD s howed the best inhibition of  α -glucosidase with an IC 50  value of 396.40 μg/mL in the antidiabetic activity.  CAH  was effective against  Staphylococcus aureus  at MIC = 312.5 µg/mL. This is the first report on antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of  C. altissima .

Assessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities