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Cinnamomum tamala  and  Cinnamomum verum  are known for their folk medicinal usage in treating gastrointestinal ailments. The spasmolytic activity of essential oils was studied using isolated rat ileum. The results indicate that  C. tamala , despite having a lower content of eugenol (60%), shows a spasmolytic potential of 68.01 ± 2.63% (EC 50  = 110.12 ± 13.58 μg/mL) while  C. verum  with rich eugenol (80%) shows lesser spasmolytic potential (38.96 ± 0.63%) and fails to attain an EC 50  value. Upon comparison with standard eugenol’s percentage of spasmolytic (35.68 ± 2.57%), it is evident that the action of these essential oils does not solely rely on the major component but the synergistic role in association with other components of the mixture influences the pharmacological action of the essential oils.  In silico  docking of phytochemicals of leaf essential oils with M 2  (M 2 AChR) and M 3  muscarinic (M 3 AChR) and nicotinic acetylcholine receptor (nAChR) was carried out to determine the type of receptors through which the essential oils had spasmolytic potential. The binding affinity for eugenol with nAChR shows a better docking score than M 2 AChR and M 3 AChR.

zeitschrift für naturforschung c

Comparative spasmolytic effect between  Cinnamomum tamala  and  Cinnamomum verum  leaf essential oils and eugenol through  in vitro  and  in silico  approaches