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Six known compounds, namely two halisulfates  1  and  2  and four epidioxy sterols  3–6 , were isolated from the marine sponge  Coscinoderma  sp. The structures of these compounds were confirmed by nuclear magnetic resonance ( 1 H and  13 C NMR) spectroscopy, and their antiplasmodial activities were determined against the chloroquine-resistant Dd2 strain of  Plasmodium falciparum . The epidioxy steroids  3–6  all showed moderate to weak antiplasmodial activity, with IC 50  values of 2.7 μM for (24 S )-5α,8α-epidioxy-24-methylcholesta-6-en-3β-ol ( 3 ), 11.6 μM for 5α,8α-epidioxycholesta-6,24(28)-dien-3β-o1 ( 4 ), 2.33 μM for 5α,8α-epidioxy-24-methylcholesta-6,9(11)-24(28)-trien-3β-ol ( 5 ), and between 12 and 24 μM for 5α,8α-epidioxycholesta-6-en-3β-ol ( 6 ). In contrast, halisulfate 2 ( 1 ) was inactive, and halisulfate 1 ( 2 ) had an of IC 50  value of about 24 μM.

Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp.