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The antibacterial-guided investigation of the stem bark extract of  Pseudocedrela kotschyi  led to the isolation of a new secotirucallane triterpene derivative: 4-hydroxy-3,4-secotirucalla-7,24-dien-3,21-dioic acid ( 1 ), together with the known one: 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic acid ( 2 ) and 3-methyl ester 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic ( 3 ). The structures of the isolated compounds were elucidated on the basis of extensive 1D- and 2D-NMR spectroscopy. Extracts, fractions and compounds ( 1–3 ) were tested in vitro for antibacterial activity against two Gram positive bacteria ( Bacillus subtilis  and  Staphylococcus aureus  ATCC 25923), and two Gram negative bacteria ( Escherichia coli  S2(1) and  Pseudomonas aeruginosa ). The MeOH extract and the Hex/CH 2 Cl 2  (70:30) fraction showed significant levels of activity (MIC=64– 256 μg/mL) compared with the two reference drugs [ciprofloxacin: MIC (0.5–1 μg/mL) and amoxicillin: MIC (1–128 μg/mL)]. Moreover, the compound  2  isolated from this Hex/CH 2 Cl 2  (70:30) fraction had the greatest potential value against  S. aureus ,  E. coli  and  P. aeruginosa , with minimum inhibitory concentrations (MIC) ranging from 4–16 μg/mL.

Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi