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The aim of the current work was to explore the muscle relaxant effect of pistagremic acid (PA) isolated from  Pistacia integerrima  in various animal paradigms. In a rotarod test, PA caused a significant (p&lt;0.05) muscle relaxant potential in a dose-dependent manner. When studied in the inclined plane test, pretreatment with PA (5 and 10 mg/kg) caused promising activity (p&lt;0.05) after treatment for 30, 60 and 90 min. The muscle relaxant potential of PA was strongly complimented by the traction and chimney tests, showing a dominant effect after 60 min of treatment. In conclusion, PA possesses strong muscle relaxant activity in various animal-based models.

Muscle relaxant activities of pistagremic acid isolated from Pistacia integerrima