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Two new limonoids, kostchyienones A ( 1 ) and B ( 2 ), along with 12 known compounds  3–14  were isolated from the roots of  Pseudocedrela kostchyi . Compound ( 7 ) was isolated for the first time from a natural source. Their structures were elucidated on the basis of spectroscopic evidence. Compounds  1–6  and  13–14  gave IC 50  values ranging from 0.75 to 5.62 μg/mL for antiplasmodial activity against chloroquine-sensitive ( Pf3D7 ) and chloroquine-resistant ( PfINDO ) strains of  Plasmodium falciparum . Compound  5  showed moderate potential cytotoxicity against the HEK239T cell line with an IC 50  value of 22.2±0.89 μg/mL. The antiplasmodial efficacy of the isolated compounds supports the medicinal value of this plant and its potential to provide novel antimalarial drugs.

Kostchyienones A and B, new antiplasmodial and cytotoxicity of limonoids from the roots of Pseudocedrela kotschyi (Schweinf.) Harms