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Caspase-1 is one of the effector caspases in mammals that plays a central role in apoptosis. However, the lepidopteran caspase-1, especially the  Bombyx mori  caspase-1  (Bm -caspase-1), has not been investigated in detail. In this study,  Bm - caspase-1  was identified from an expressed sequence tag database in  B. mori  by BLAST search. The open reading frame of  Bm-caspase-1  contained 879 nucleotides and encoded 293 amino acids with a predicted molecular mass of 33 kDa.  Bm- caspase-1 contained two consensus amino acid motifs of caspase cleavage sites, DEGDA and TETDG. Caspase activity assays revealed significant proteolytic activity of the Ac-DEVD-pNA substrate.  Bm - caspase-1  can be detected in all tissues and developmental stages by a semi quantitative polymerase chain reaction assay. More importantly, the expression level of  Bm - caspase-1  is increased upon baculovirus infection and up-regulated in BmNPV-resistant silkworms. Taken together, these results indicate that  Bm -caspase-1 plays an important role during baculovirus infection.

Caspase-1 from the silkworm, Bombyx mori, is involved in Bombyx mori nucleopolyhedrovirus infection