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3-(2,4-Dihydroxyphenyl)propionic acid (DDPA) and  l -ascorbic acid (vitamin C) show tyrosinase inhibition activity. A synergistic effect on tyrosinase inhibition was observed when the two compounds were mixed. The effect significantly decreased the IC 50  value of both compounds.

The evaluation of the synergistic effect of 3-(2,4-dihydroxyphenyl)propionic acid and l -ascorbic acid on tyrosinase inhibition