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N-alkyl substituted 2′,3″-thiazachalcones {3-[(1 E )-3-(4-methylthiophene-2-yl)-3-oxoprop-1-en-1-yl]-1-alkyl (C 5–12,14 ) pyridinium bromides} were synthesized by a two-step reaction. The newly synthesized compounds were characterized by IR,  1 H NMR,  13 C NMR, elemental analysis and mass spectral studies. The synthesized compounds were tested for antibacterial activities and found to be more active against Gram-positive as compared to Gram-negative bacteria.

Synthesis and antimicrobial properties of N-substituted derivatives of ( E )-2′,3″-thiazachalcones