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Diversely sourced degradation products of higher plant lignans were identifi ed in modern and ancient woodrat (Neotoma) middens. The markers indicate extensive chemical modifi cation by intestinal microbial communities of mammals. The observed defunctionalized phenols represent a group of natural products, and their structural elements reveal information about the plant source. The phenols are derived mainly from two precursor types: (1) enterolactone and derivatives from conifer lignans, and (2) 2,3-bis(3’-hydroxybenzyl)butane and related compounds from lignans such as nordihydroguaiaretic acid common in Larrea sp. (e.g. creosote bush)

Enterolactone and Other Lignan Metabolites as Taxon-Specifi c Markers in Modern and Ancient Woodrat Middens