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The pyrimidine thione derivatives 2a - d were prepared by the reaction of thiourea, ethyl cyanoacetate and several aromatic aldehydes. The acyclic thioglycosides 4a - 7d were prepared by the reaction of the synthesized pyrimidine thiones 2a - d with different alkyl halides, whereas the reaction of 2a - d with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide afforded the cyclic thioglycosides 8a - d whose deprotection afforded 9a - d. The obtained compounds were tested for their antischistosomal and antiviral activity against hepatitis B virus (HBV). Compounds 5a, 5d, 7a showed high activity against HBV using the MTT assay; moreover compounds 5c, 6d, 7a, 9a, 9c exhibited high activity as antischistosomal agents.

Antiviral and Antischistosomal Evaluation of Newly Synthesized Thioglycosides and their Acyclic Analogues