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The effect of different L-phenylalanine (Phe) concentrations (0.12-12.1 mм) on acetylcho­ linesterase (AChE), (Na + ,K + )-ATPase and Mg 2+ -ATPase activities was investigated in homogenates of adult rat whole brain and frontal cortex at 37 °C. AChE, (Na + ,K + )-ATPase and Mg 2+ -ATPase activities were determined after preincubation with Phe. AChE activity in both tissues showed a decrease up to 18% (p&lt;0.01) with Phe. Whole brain Na + ,K + -ATPase was stimulated by 30-35% (p&lt;0.01) with high Phe concentrations, while frontal cortex Na + ,K + -ATPase was stimulated by 50-55% (p&lt;0.00l). Mg 2+ -ATPase activity was increased only in frontal cortex with high Phe concentrations. It is suggested that: a) The inhibitory effect of Phe on brain AChE is not influenced by developmental factors, while the stimulation of Phe on brain Na + ,K + -ATPase is indeed affected; b) The stimulatory effect of Phe on rat whole brain Na + ,K + -ATPase is decreased with age; c) Na + ,K + -ATPase is selectively more stimulated by high Phe concentrations in frontal cortex than in whole brain homogenate; d) High (toxic) Phe concentrations can affect Mg 2+ -ATPase activity in frontal cortex, but not in whole brain, thus modulating the amount of intracellular Mg 2+ .

Effects of ʟ-Phenylalanine on Acetylcholinesterase, (Na + ,K + )-ATPase and Mg 2+ -ATPase Activities in Adult Rat Whole Brain and Frontal Cortex