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Comparative kinetic studies on the oxidation of catecholamines (CA) (dopamine (DA), epinephrine (EP). norepinephrine (NEP)) serving as a neuromediator in the sympathetic nervous system, 3,4-dihydroxyphenylalanine (DOPA) and 6-hydroxydopamine (6-OHDA), a wellknown neurotoxic agent, were performed in the presence of ascorbate (AscH -  ) in 50 mᴍ phosphate buffer, pH 7.40, at 37 °C by using a Clark electrode, EPR and the absorption spectroscopy. The oxidation of CA and DOPA alone was found to be a self-accelerating process, with quinone products (Q) acting as autocatalysts. The rate of oxygen consumption (R ox ) increased with time and reached a steady-state level. A starting value of R ox  increased in the order: EP &lt; DOPA ≈ NEP ≪ DA ≪ 6-OHDA, whereas a steady-state value of R ox  changed in the order: DOPA &lt; DA &lt; NEP ≪ EP ≪ 6-OHDA. The changes in R ox  with time were found to correlate with the resistance of primary Q to the intramolecular cyclization.

The Oxidation of Catecholamines and 6-Hydroxydopamine by Molecular Oxygen: Effect of Ascorbate