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This study shows that incubation of rat liver mitochondria in the presence of the thiol/ amino reagent 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DID S) is followed by inhibition of both succinate supported respiration and oxidative phosphorylation. Half-maximal inhibition of succinic dehydrogenase activity and succinate oxidation by mitochondria was attained at 55.3 and 60.8 μm DIDS, respectively. DIDS did inhibit the net ATP synthesis and ATP ⇔ [ 32 P]Pi exchange reaction catalyzed by submitochondrial particles in a dose-dependent manner (K i = 31.7 μm and K i  = 32.7 μm), respectively. The hydrolytic activities of uncoupled heart submitochondrial particles and purified F  1  -ATPase were also inhibited 50% by 31.9 and 20.9 μm DIDS, respectively.

Inhibition of Succinic Dehydrogenase and F 0 F 1 -ATP Synthase by 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic Acid (DIDS)