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The glycogenolytic-sarcoplasmic reticulum complex from rat skeletal muscle accumulates Ca 2+  upon stimulation of glycogen phosphorolysis in the absence of added ATP. It is shown that an efficient Ca 2+  uptake involves the sequential action of glycogen phosphorylase, phosphoglucomutase and hexokinase, which generate low concentrations of ATP (approximately 1 -2 μм) compartmentalized in the immediate vicinity of the sarcoplasmic reticulum Ca 2+ , Mg 2+ -ATPase (the Ca 2+  pump). The Ca 2+  uptake supported by glycogenolysis in this subcellular structure is strongly stimulated by micromolar concentrations of AMP, showing that the glycogen phosphorylase associated with this complex is in the dephosphorylated b form. The results point out that the flux through this compartmentalized metabolic pathway should be enhanced in physiological conditions leading to increased AMP concentrations in the sarcoplasm, such as long-lasting contractions and in ischemic muscle.

Ca 2+ Uptake Coupled to Glycogen Phosphorolysis in the Glycogenolytic-Sarcoplasmic Reticulum Complex from Rat Skeletal Muscle