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In a screening for inhibitors of fungal melanin biosynthesis a novel test system was success­ fully employed. With this test system, based on the production of dihydroxynaphthalene melanin (DHN melanin) by a Lachnellula species in agar cultures, extracts of cultures of basidiomycetes, ascomycetes and deuteromycetes were tested. From fermentations of Col-lybia dryophila, 6-methylpurine (1) and 6-methyl-9-β-ᴅ-ribofuranosylpurine (2) were isolated as the active principles and 3,5-dichloro-4-methoxybenzoic acid (3) was obtained from cultures of Stropharia squamosa. The corresponding alcohol (4) and aldehyde (5) previously isolated from several basidiomycetes, were also active in this test system. In a screening of fungal metabolites, 1-methoxy-8-hydroxynaphthalene and 1,8-dimethoxynaphthalene inhibited biosynthesis of DHN melanin.

Fungal Melanin Biosynthesis Inhibitors: Introduction of a Test System Based on the Production of Dihydroxynaphthalene (DHN) Melanin in Agar Cultures