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received October 23, 1993/March 1, 1994 Ethanol, Microsomes, Mitochondria, Lipid Peroxidation, Hepatotoxicity A group of male rats were intoxicated within 24 h by three successive i.p. doses of ethyl alcohol (7.5 g per 1 kg of the body weight). In parallel, a control group of rats were dosed i.p. with a physiological saline. At time intervals of 0 h, 4 h, 24 h, and 48 h after the intoxi­ cation, the content of thiobarbiturate-reactive substances (TBARS) as product of lipid per­ oxidation within the liver and brain microsomes and mitochondria was followed.

Temporal Changes of the Lipid Peroxidation in Rats after Acute Intoxication by Ethanol