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14-Epicochlioquinone B (1) and 14-epidihydrocochlioquinone B (2) were isolated from sub­ merged cultures of Neobulgaria pura (Pers. ex Fr.) Petrak. 14-Epicochlioquinone B is a potent inhibitor of hum an and bovine platelet aggregation stimulated by different inducers. 14-Epidihydrocochlioquinone B does not inhibit the aggregation of platelets. In addition, both 1 and 2 exhibited cytotoxic and antimicrobial activites.

zeitschrift für naturforschung c

4-Epidihydrocochlioquinone B and 14-Epicochlioqumone B, Antibiotics from Fermentations of the Ascomycete Neobulgaria pura: Structure Elucidation and Effects on Platelet Aggregation