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Two antifungal metabolites isolated from Calcarisporium thermophilum were identified as 15-azahom osterols related to the compounds previously isolated from Geotrichum Jlavo-brun-neum. By full spectral comparison with authentic 15-aza-24-methylene-D-homocholesta-8,14-dien-3 β-ol (A 25822 B) from G. flavo-brunneum, the Calcarisporium metabolites were characterized as the 4a-m ethyl-and 4,4-dimethyl-analogues of A 25822 B. Several minor members of the series were also detected, and tentatively identified by MS analysis. The 15-azahom osterols exhibited good antifungal activity towards Candida parapsiliosis, though the activities were somewhat lower than that of the 4-demethyl derivative A 25822 B. Calcarisporium thermophi­lum is the second microorganism known to synthesize these unusual 15-azahomosterol deriva­tives.

Antifungal Antibiotics from Calcarisporium thermophilum: A New Source of 15-Azahomosterol Derivatives