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Differential pulse polarography study was used to investigate the influence of glutathion on cis-and trans-DDP induced alterations of DNA structure. Though the applied concentration of glutathion has no effect on the reaction of DNA with cis -DDP , it greatly modifies the reac­tion with trans isomer. This may be an important reason for the ineffectivness of the trans-DDP as an antitumor drug.

The Effect of Glutathion on the Reaction of cis-and fra/25-Diamminedichloroplatinum(II) with DNA