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Exposing native calf thymus DNA (in 0.1 м NaClO 4- , 5 mм cacodylic acid buffer, pH 6.81, 25 °C) to increasing concentrations of Hg(C 104)2 produces dramatic changes in its circular dichroism (C D ). Let r = [mol of added Hg(II)*/[mol DNA base]: the conservative CD spectrum of the DNA B-form, consisting of the 273 nm major ( + ) C D band, the 245 nm major ( -) C D band, the 219 nm minor ( + ) CD band, and the 208 nm minor ( -) CD band, becom es non-conservative in appearance at 0.01 &lt; r &lt; 0.12 and assumes the spectral characteristics of a left-handed D N A double helix at 0.12 &lt; r &gt; 1.0. The presence of a number of isoellipticity points shows that welldefined equilibria exist between the various chiroptical forms of mercurated DNA . The CD changes are totally reversible upon the removal of H g(II), at least up to r = 1.0, demonstrating that H g(II) keeps all base pairs in register.

Hg(II)-Induced Changes in DNA-Circular Dichroism: Reversible Transitions between Right-Handed and Left-Handed Screwness