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The tetrahydroisoquinoline alkaloids salsolidine (1-methyl- 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline) and 1- carboxysalsoline (1-carboxy-1-methyl-6-hydroxy-7-methoxy- 1,2,3,4-tetrahydroisoquinoline), which are themselves not substrates for the enzyme catechol-O-methyltransferase, are - contrary to a hitherto existing view - able to inhibit competitively the methylation of the catecholamine metabolite 3,4-dihydroxybenzoic acid by the enzyme enriched from rat liver. The inhibitor constants were determined to be K i  = 0.19 mM for salsolidine and K i  = 0.44 mM for 1-carboxysalsoline.

Kompetitive Hem m ung der Catechol-O-Methyltransferase durch die Tetrahydroisochinolin- Alkaloide Salsolidin und 1-Carboxysalsolin