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The preparation of the four stereoisomers of propiconazole (TILT ® ) is described. Their inhibition of the 14α-C-demethylation of the sterol nucleus is examined and compared with the inhibition by the four stereoisomers of etaconazole (SONAX ® ). The quantitative structure-activity relationships (QSAR) of substituted 1,3-dioxolane-2-yl-methyltriazoles and 1,3-dioxane-2-ylmethyltriazoles on in vivo fungicidal activity are investigated.

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Quantitative Structure Activity Relationships of Fungicidally Active Triazoles: Analogs and Stereoisomers of Propiconazole and Etaconazole Quantitative Structure Activity Relationships of Fungicidally Active Triazoles: Analogs and Stereoisomers of Propiconazole and Etaconazole