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Repeated immunizations of rabbits with chemically synthesized peptides from selected regions of HLA-DP histocompatibility antigens resulted in the production of specific antibodies that were then isolated from the immune sera by chromatography on Sepharose-peptide immunoadsorbents.

Recognition of HLA Class II Molecules by Antipeptide Antibodies Elicited by Synthetic Peptides Selected from Regions of HLA-DP Antigens