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Metabolism, [4- 13 C]Phenacetin, Continuous Flow  13 C NMR Continuous flow  13 C NMR spectroscopy has been used for the first time to monitor the metabolism of a  13 C labeled drug in an isolated liver. Continuous and almost immediate information on the metabolite formation could be obtained using  13 C labeled phenacetin without alteration of the biological system. The data are consistent with those observed by conventional techniques (HPLC, aliquot  13 C NMR measurements). From the biological point of view the sensitivity of continuous flow  13 C NMR spectroscopy is still low (10 -3  ᴍ). The results presented demonstrate however that non-invasive and non-radio-active real time monitoring of drug metabolism in intact organs is possible.

Notizen: In vivo Metabolism of [4- 13 C]Phenacetin in an Isolated Perfused Rat Liver Measured by Continuous Flow 13 C NMR Spectroscopy