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Under adequate experimental conditions calmodulin antagonists like compound 48/80 do not dissociate calcium uptake from the calcium -dependent ATP hydrolysis of skeletal muscle sarcoplasmic reticulum membranes but simultaneously inhibit both processes. Apart from the agent’s pump inhibiting effect, they interact with the caffeine sensitive calcium channel in the sarcoplasmic reticulum causing a rapid transient calcium release.

zeitschrift für naturforschung c

Inhibitors of Calmodulin-Dependent Phosphorylation Simultaneously Inhibit Calcium Uptake and Calcium-Dependent ATPase Activity in Skeletal Muscle Sarcoplasmic Reticulum and Transiently Induce Calcium Release