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Male mice were i.p. injected with two doses (5&amp;15 mg/kg body weight) of [1- 14 C]ethyl-labelled chlorpyrifos. The radioactivity in liver, fat, kidney and urine was measured 6, 24, 48, and 192 h after treatment. Liver RNA and DNA were isolated and hydrolyzed and the bases separated by ion-exchange chromatography. Radioactivity resulting from incorporation and alkylation of RNA and DNA was measured. Labelled 7-ethylguanine was found in RNA hydrolysate which amounted 5.5 × 10 -3  calculated as fraction of the applied dose. In DNA hydrolysate [ 14 C]7-ethylguanine was missing and the major radioactivity was found in two unknown peaks, one of which corresponds to 3 × 10 -2  of the applied dose. The results indicate that the extent of alkylation obtained with clorpyrifos is high as compared with other organophosphates with methyl esters.

Bioalkylation of Nucleic Acids in Mice by Insecticides. I. Alkylation of Liver RNA and DNA by Chlorpyrifos