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We report on the chemical preparation of the NAD +  analog P1, P2-(5′-β-nicotinamideribofuranosyl-3″-adeno-syl)-diphosphate (N3″AD + ) by applying the 1,1′-carbonyl-diimidazole activation method. The importance of how adenosine is linked to the nicotinamide mononucleotide phosphoriboride (NMNPR + ) moiety is discussed with re­ spect to the coenzyme activity in the lactate dehydrogenase catalyzed reaction.

zeitschrift für naturforschung c

Die Bedeutung der Verknüpfungsposition des Adenosins im NAD +  für die Coenzymaktivität gegenüber Lactatdehydrogenase / The Importance of the Position of the Adenosine Linkage in NAD +  for Its Coenzyme Activity via Lactate Dehydrogenase