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From the culture filtrate of Streptomyces griseus strain 587 a herbicidal active fraction was isolated by adsorption on Lewapol ®  , methanolic desorption, and chromatography on Sephadex ®  LH-20. Further purification was achieved by HPLC. The pure product was characterized by TLC and different colour reactions. By MS,  1 H-NM R, IR and ORD spectroscopy the herbicidal compound could be identified as naramycin B. Naramycin B is an optical isomer of cycloheximide (naramycin A, Actidione ® , Acti-Aid ® ). This communication reports on the fermentative production of naramycin B with strain 587, its isolation, identification, and herbicidal activity.

Naramycin B, an Antibiotic from Streptomyces griseus Strain 587 with Herbicidal Properties-Fermentation, Isolation, and Identification