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The membrane-bound, solubilized, and trypsin-treated forms of Mg, Ca-ATPase from E. coli are inhibited by ruthenium red[R R ]. The inhibition is noncompetitive and is reduced at higher sub strate concentrations. n-Butanol-extracted ATPase is not inhibited by ruthenium red and is not activated by KCl.

Inhibition of Mg, Ca-ATPase from E. coli by Ruthenium Red