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Neighbouring pyramidal cells in the mouse cortex sometimes have different densities of dentritic spines. This was shown by a quantitative analysis of 10 neurons. For this, a method was worked out which corrects for the spines hidden behind (and in front of) the dendrite. The main result is that there is a positive correlation between the spine densities on different parts of the dendritic tree of one neuron. The possible functional meaning of these findings is briefly discussed.

Pyramidal Cells with Different Densities of Dendritic Spines in the Cortex of the Mouse