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Diphosphonates, Dissociation Constants The dissociation constants of ethane-l-hydroxy-1,1-disphosphonate [EHDP] and dichloro-methylene-diphosphonate [Cl 2 MDP] for H + , Ca 2+ , Mg 2+  and Zn 2+  have been determined from pH-titration curves. EHDP forms more stable chelates with Ca 2+ , Mg 2+  and Zn 2+  than Cl 2 MDP. Cl 2 MDP is a stronger acid than EHDP.

Dissociation Constants of Ethane-1-hydroxy-1,1-diphosphonate [EHDP] and Dichloromethylene-diphosphonate [Cl 2 MDP] for H + , Ca 2+ , Mg 2+ and Zn 2+