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Metaphase chromosomes of group A isolated from the imipramine-treated lymphocyte cultures did bind more tritiated poly-ʟ-lysine ( 3 H-PL) than the control chromosomes. The increase in binding was dependent on the length of treatment and on contraction of chromosomes. The effect of contraction was more pronounced for the treated chromosomes than for controls and was larger when the treatment was done 4 hours before termination of culture. The observed differences in the  3 H-PL binding probably reflect differences in the chromosomal surface morphology

Effect of imipramine on human chromosomes studied by the method of poly-l-lysine binding