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An antagonistic influence of lithium and thiocyanate ions on the metabolism of nucleic acids has been demonstrated in Tetrahymena pyriformis. This effect corresponds to morphogenetic observations on other ciliates. Similar investigations on mammalian cells (L-cells, CV I-cells, Chang-livercells, HeLa-cells, and ascites tumor cells of Walker-carcinosarcoma 256, Yoshida-sarcoma, Zajdelahepatoma) showed, in contrast to the results in Tetrahymena, no antagonistic influence of lithium and thiocyanate ions: Both ions inhibit the DNA-synthesis, in tumor cells as well as in normal cells.

zeitschrift für naturforschung c

Wirkung von Lithium- und Rhodanidionen auf den Nukleinsäure-Stoffwechsel von Tetrahymena pyriformis, normalen und neoplastischen Säugerzellen / Effect of Lithium and Thiocyanate Ions on the Metabolism of Nucleic Acids of Tetrahymena pyriformis, Normal and Neoplastic Mammalian Cells