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Chemical investigation of the roots of  Trichilia welwitschii  yielded a cycloartane type terpenoid 28,29-bis-norcycloart-24-en-3 β ,4 α ,6 α -triol ( 1 ), isolated as pure compound for the first time, three coumarins and three sterols. New cycloartane derivatives ( 1a ) and ( 1b + 1c ) were obtained by hemi-synthetic reaction of compound  1 . The structures of  1a – c  were established by spectroscopic methods including 1D and 2D-NMR analysis, HR-EIMS, chemical transformations and by comparison of these data with those of related compounds. Evaluated for their antimycobacterial potential, compound  1  and  1b + 1c  were determined to show significant activities against  Mycobacterium tuberculosis  MIC values of 6.25 μg mL −1  while compound  1a  displayed weak activity showing MIC &gt; 100 μg mL −1 . Compounds  2 – 4  displayed moderate activity with MIC values range from 12.5 to 50 μg mL −1 .

Antimycobacterial cycloartane derivatives from the roots of Trichilia welwistchii C. DC (Meliaceae)