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From an ethyl acetate extract of twigs and barks of  Dacrydium elatum  a new diterpenoid named dacrydianone ( 1 ), together with lambertic acid ( 2 ), three ecdysteroids: 20-hydroxyecdysone ( 3 ), ajugasterone C ( 4 ), ponasterone A ( 5 ), and daucosterol ( 6 ), has been isolated. Their structures were elucidated by an extensive analysis of the UV/Vis, FT-IR, MS and NMR spectra as well as comparison with those in published literature. The EtOAc extract and the isolated compounds  1–5  were evaluated for their cytotoxicity on four cancer cell lines: breast cancer (MCF-7), lung cancer (Lu-1), liver cancer (HepG2) and human oral cancer (KB). The EtOAc extract and compound  2  showed a medium activity on four tested cancer cell lines, while compounds  3  and  5  exhibited week activity on these cell lines. Compounds  1  and  4  did not show activity on the tested cell lines.

Study on the chemical constituents of Dacrydium elatum and their cytotoxic activity