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A new series of chalcones, pyrazolinyl-pyrazoles, pyrazole-4-carbaldehyde oximes, pyrazole-4-carbonitriles, 5-pyrazolyl-1,2,4-triazolidine-3-thiones, and Knoevenagel condensation products was synthesized from 3-aryl-1-phenyl-1 H -pyrazole-4-carbaldehydes. Most reactions were carried out either without solvent or in the presence of water as a green solvent. The structure of synthesized compounds was characterized by spectral and elemental analysis. The synthesized compounds were tested  in vitro  for their antimicrobial activity against  Escherichia coli ,  Staphylococcus aureus , and  Candida albicans  in comparison with imipenem (intravenous  β -lactam antibiotic) and clotrimazole (antifungal medication) as reference drugs by using the agar diffusion technique. 3-Aryl-1-phenyl-1 H -pyrazole-4-carbonitriles  8b ,  8c , and  8d  showed significant antifungal activity against the fungus  C. albicans .

Synthesis and antimicrobial evaluation of some heterocyclic compounds from 3-aryl-1-phenyl-1 H -pyrazole-4-carbaldehydes