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In the search for new bioactive compounds from extremophilic actinomycetes, a new marine actinomycete strain,  Nocardiopsis lucentensis  sp. ASMR2 has been isolated and taxonomically identified from marine plants collected in the Red Sea at Hurghada coasts. A large-scale fermentation of the strain on modified rice solid medium was performed, followed by work-up and purification of the obtained extract using a series of chromatographic purifications, delivering the novel butenolide system 3′-hydroxy- N -(2-oxo-2,5-dihydrofuran-4-yl)propionamide ( 1a ) along with the naturally new 4-methoxy-2 H -isoquinolin-1-one ( 2 ). Furthermore, eight known bioactive compounds are also reported, namely, indole-3-carboxylic acid, indole-3-acetic acid, indole-3-acetic acid methyl ester, furan-2,5-dimethanol, tyrosol, glycerol linoleate, cyclo-(Tyr, Pro), and adenosine. The chemical structures of the new compounds ( 1a ,  2 ) were confirmed by extensive one- and two-dimensional (1D and 2D) nuclear magnetic resonance (NMR) spectroscopy, electron ionization high resolution (EI-HR) mass spectrometry, and by comparison with literature data. The antimicrobial activity of the strain extract, as well as of compounds  1a  and  2 , were studied using a panel of pathogenic microorganisms. The  in vitro  cytotoxicity of the bacterial extract and compounds  1a  and  2  were studied against the human cervix carcinoma cell line (KB-3-1) and its multidrug-resistant subclone (KB-V1).

New bioactive compounds from the marine-derived actinomycete Nocardiopsis lucentensis sp. ASMR2