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Nine phenylethanoid glycosides were isolated from Buddleia lindleyana. On the basis of spectral analyses, their structures were elucidated to be acteoside (1), echinacoside (2), citanoside A (3), leucosceptoside A (4), leucosceptoside B (5), pedicularioside A (6), isoacteoside (7), arenariside (8), and a new compound named buddleoside A (9). The eight known compounds were isolated from this plant for the first time. The neuroprotective effects of compounds 1 (acteoside), 5, 6, 8 and 9 on the 1-methyl-4-phenylpyridinium ion (MPP + )-induced cell death in mesencenphalic neurons were investigated. Mesencenphalic neurons treated with MPP +  underwent cell death as determined by MTT assay. Simultaneous treatment with the phenylethanoid glycosides markedly attenuated MPP + - induced cytotoxicity.

Bioactive Phenylethanoid Glycosides from Buddleia lindleyana