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An improved synthesis of 6-O-benzyl guanine which is an important inhibitor of O 6 -alkyl-guanine DNA alkyltransferase (AGT) is described. In addition the conjugation of this guanine derivative was achieved with a functionalised hydrophilic linker which is of interest for immobilisation of this inhibitor and its conjugation with targeting components.

Synthese von 6-O-Benzylguanin und seinen Anker-Konjugaten / Synthesis of 6-O-Benzyl Guanine and its Conjugations with Linkers