English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The synthesis of the following thioethers of 2-chloro-6-mercaptopurine is described: 2-chloro-6-[4-phenyl-imidazole-2-thio] purine; 2-chloro-6- [4-guanidopropyl-imidazole-2-thio] purine; 2-chloro-6-[4-t.butyl-thiazole-2-thio] purine; 2-chloro-6- [4-phenyl-thiazole-2-thio] purine; 2-chloro-6- [4-methylthiazole-2-thio] purine; 2-chloro-6- [4-carbethoxymethyl-thiazole-2-thio] purine; 2-chloro-6- [4-carboxamido-5-amino-thiazole-2-thio] purine; 2-chloro-6- [5-phenyl-thiadiazole (1,3,4) -2-thio] purine; 2-chloro-6- [5-t.butyl-thiadiazole (1,3,4) -2-thio] purine; 2-chloro-6- [tetrazole-5-thio] purine. The thioether bond of these compounds is cleaved by nucleophilic agents especially by mercaptanes under mild conditions. The compounds are not metabolized by ascites cells and preferentially bound to the cell surface. They are inhibitors of DNA-, RNA-, and proteinsynthesis and of proliferation of Ascites cells in a different degree; the ascites carcinoma of mice was not influenced. A possible mechanism of action of their metabolic effects is discussed.

zeitschrift für naturforschung b

Synthese und biochemische Eigenschaften von heterocyclischen Thioäthern des 2-Chlor-6-mercaptopurins / Synthesis and Biochemical Properties of Heterocyclic Thioethers of 2-Chloro-6-mercaptopurine