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Synthetic polynucleotides are able to stimulate the synthesis of interferon and confer a virus-refractive state to animal cells 1. Previous results by SCHÄFER and LOCKART have presented evidence supporting the notion that the virus resistant state of monkey cells treated with polynucleotides is due to the interferon producing capacity of polyinosinicpolycytidylicacid (poly (rl) • po ly ( rC) ) 2. These results are consistent with findings of TAYLOR and MATSUYAMA et al . , w h o have shown that the inhibition of Sindbis Virus by poly(r l ) poly (rC) similarly to the inhibition by interferon can be counteracted if the preincubation of the cells with the doublestranded polynucleotide is carried out under conditions of inhibited cellular RNA-synthesis 3 ' 4. On the other hand, direct effects of the polynucleotides on virus specific RNA-synthesis have been observed 3. Results are presented showing that the inhibition of Semliki Forest Virus replication by poly(r l ) -poly(rC) is reversed under conditions of reduced RNA-synthesis which suggest that the inhibitory action of the polymer is not a direct effect on viral macromolecule synthesis but is mediated by substances, which are induced during the exposure of chick embryo cells to poly (rl ) -po ly ( rC) .

Notizen: Requirement of Cellular RNA-synthesis for the Inhibition of Semliki Forest Virus by poly (rI) · poly (rC)