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The question of a possible relationship between the RNA content of poliovirus and its reactivity as N- or H-antigen was examined with double-labeled virus preparations ( 32 P-RNA,  14 C-Protein). The following results were obtained: 1. Complete virus particles containing RNA may be N- or H-reactive. 2. Heat inactivation of poliovirus causes dissociation of capsid and RNA. 3. Under certain experimental conditions of thermal inactivation, the N/H conversion preceeds RNase sensitivity of viral RNA.

zeitschrift für naturforschung b

RNA Gehalt und Antigeneigenschaften von Polioviren vor und nach Hitzeinaktivierung / RNA Content and Antigenicity of Polioviruses before and after Inactivation by Heating