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It is shown that the 1700 × g supernatant of human lymphocytes stimulated with phytohaemagglutinin had an inhibitory, but not a lytic, effect on the permanent tissue sulture cell strain of Fl-cells. The factor called proliferation inhibition factor seems to be a protein. The incorporation of H 3 -thymidin into DNA was affected more and earlier than the incorporation of H 3 -uridin into RNA or C 14 -Leucin into protein of the cultured cells. There was no effect on respiration or glycolysis.

zeitschrift für naturforschung b

Über die Wirkung eines Hemmfaktors aus Kulturen stimulierter Lymphocyten auf eine permanente Gewebe-Zellinie: The Effect of the Proliferation Inhibition Factor from the Culture of Stimulated Human Lymphocytes on a Permanent Cell Strain