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The effect of a semisynthetic pentosan-polysulfo-ester (SP 54) upon the complement system in vitro has been studied in comparison with the effects of heparin. Both substances inhibit in small concentrations the Cl-esterase. There are differences in the effect of SP 54 and heparin. According to the in vitro results SP 54 seems to have a ten times higher anticomplementary action. At the same time the influence upon coagulation is less. SP 54 appears to be a substance of therapeutic interest.

zeitschrift für naturforschung b

In vitro-Untersudiungen über Angriffspunkt und Wirkungsunterschiede zum Heparin / In Vitro Studies on the Mode of Action and Differences to Heparin: Antikomplementäre Wirkung eines semisynthetischen Pentosan-Polysulfo-Esters / Anticomplementary Effect of a Semisynthetic Pentosan-Polysulfo-Ester