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The sparing effect of UV- and X-ray dose fractionation and the influence of pre-exposure starvation were investigated in diploid yeast, Saccharomyces cerevisiae. A sparing effect could be demonstrated in starved cells if they were incubated in fresh nutrient medium during the fractionation interval. The time necessary for complete recovery, however, was greatly increased as compared to unstarved stationary phase cells. The possible role of cell progression and partial synchronization is discussed.

The Sparing Effect of UV- and X-ray-dose-fractionation in Starved Diploid Yeast