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Female rats have been employed for a study of the reactivity of zinc ions on RNA and protein biosynthesis of liver nuclei. Intraperitoneal injections of 20 μmoles of this metal ion have been found to stimulate RNA biosynthesis up to 80% and a 40% increase of protein synthesis was observed under the same conditions. The precursor for RNA synthesis was [6- 14 C] -orotic acid and [l- 14 C]-ᴅʟ-leucine served as a label for nuclear protein. Low Zn 2 ®-concentrations showed no reactivity, even when zinc-deficient rats were used.

zeitschrift für naturforschung b

Zur Wirkung von Zn 2⊕  auf die nucleare RNA- und Proteinbiosynthese der Rattenleber / Effect of Zn 2⊕  on Nuclear RNA- and Protein-Biosynthesis in Rat Liver