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The intestinal absorption of cyanocobalamin and aquocobalamin was measured in human beings after the oral application of 50, 100, 200 and 500 μg doses with a whole body retention test using a 4 π large volume radioactivity detector with organic scintillator. Cyanocobalamin and aquocobalamin are absorbed in man to the same degree after physiological oral doses (0.1 — 1 μg) as after unphysiologically high oral doses (50 — 500 μg). The absorption rate decreases from 4.2% (after 50 μg) to 1.2% (after 500 μg) with increasing oral dose. The daily oral uptake of 200 μg in a single dose or 50 μg twice as cyanocobalamin or aquocobalamin covers the whole body vitamin B 12  requirement of 2.55 μg vitamin B 12 /day for man. Although cyanocobalamin and aquocobalamin are artifical products not existing in nature they are easily converted within the human body into the C 5 ′-deoxyadenosyl — or coenzyme — derivative of vitamin B 12  which is the original storage and bioactive form of vitamin B 12  in mammals. Cyanocobalamin and aquocobalamin are of equal value in the prophylactic and therapeutic application of vitamin B 12  in medicine.

zeitschrift für naturforschung b

Intestinale Resorption und Gesamtkörper-Retention des  60 Co-Cyanocobalamin und  60 Co-Aquocobalamin beim Menschen nach oraler Verabfolgung unphysiologisch hoher Dosen