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A tetrahydrobiopterin-derivative and a yellow pteridine, accumulated in the eyes of the sepia mutant of Drosophila melanogaster, are very active growth factors for Crithidia fasciculata. Of the three additional pteridines found in the wild-type D. melanogaster, a dark red pteridine, neodrosopterin, is very active whereas a brick-red pteridine, drosopterin, is moderately active and isodrosopterin, probably the isomer of drosopterin is inactive. The relationships of the results of the growth experiments to the naturally-occurring eye pteridines and to the basic biopterin structure are discussed.

Wuchsstoffaktivität der Augenpterine von Drosophila melanogaster bei Crithidia fasciculata